Tea Tree Oil in the shampoo has antifungal properties as well as being antiseptic. Another ingredient Citronella Oil is a natural plant based insect repellent. The shampoo is coconut based and all natural with no harsh detergents, synthetic perfumes, or artificial colors making it safe for puppies. Shampoos size is 16 oz and includes a pump dispenser and the spritz is 4 ounces. Both are made in the USA.